500mg of 5-MeO-iPT (as freebase chunks)
Structural isomer of 5-MeO-MET with similar profile/properties when screened in-vitro.
“In vitro studies on rat brain and human receptors in transfected cells.
Twenty-one tryptamines (including 5-MeO-NIPT) were compared for their activity
at 5-HT 1A and 5-HT 2A receptors and the transporter. 5-MeO-NIPT
was judged to be a 5-HT 2A receptor agonist with a high degree of potency (EC50 =
9.24 nM). 5-MeO-NIPT showed activity at the 5-HT transporter, which
inhibits the reuptake of serotonin, but its potency (IC50 = 5442 nM)
was judged to be low compared to e.g. 5-MeO-DIPT (IC 50 = 646 nM). 5-
MeO-NIPT lacked activity at the 5-HT 1A receptor, dopamine and
the norepinephrine transporters (EC 50 /IC50 >10000 nM) (Blough et al., 2014).”
…”5-MeO-NIPT has been sold and discussed as a hallucinogenic substance. Its
psychoactive effects are compared with those of other 5-methoxy substituted
indole alkylamines (tryptamines) and are considered to have a hallucinogenic effect and give
euphoria (Drogforum, 2019; Webshop, 2019).”